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Molecular Genetics of Mycobacteriophages.


ABSTRACT: Mycobacteriophages have provided numerous essential tools for mycobacterial genetics, including delivery systems for transposons, reporter genes, and allelic exchange substrates, and components for plasmid vectors and mutagenesis. Their genetically diverse genomes also reveal insights into the broader nature of the phage population and the evolutionary mechanisms that give rise to it. The substantial advances in our understanding of the biology of mycobacteriophages including a large collection of completely sequenced genomes indicates a rich potential for further contributions in tuberculosis genetics and beyond.

SUBMITTER: Hatfull GF 

PROVIDER: S-EPMC4199240 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Molecular Genetics of Mycobacteriophages.

Hatfull Graham F GF  

Microbiology spectrum 20140301 2


Mycobacteriophages have provided numerous essential tools for mycobacterial genetics, including delivery systems for transposons, reporter genes, and allelic exchange substrates, and components for plasmid vectors and mutagenesis. Their genetically diverse genomes also reveal insights into the broader nature of the phage population and the evolutionary mechanisms that give rise to it. The substantial advances in our understanding of the biology of mycobacteriophages including a large collection  ...[more]

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