Ontology highlight
ABSTRACT:
SUBMITTER: Haelterman NA
PROVIDER: S-EPMC4199363 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Genome research 20141001 10
Forward genetic screens using chemical mutagens have been successful in defining the function of thousands of genes in eukaryotic model organisms. The main drawback of this strategy is the time-consuming identification of the molecular lesions causative of the phenotypes of interest. With whole-genome sequencing (WGS), it is now possible to sequence hundreds of strains, but determining which mutations are causative among thousands of polymorphisms remains challenging. We have sequenced 394 mutan ...[more]