Ontology highlight
ABSTRACT:
SUBMITTER: Mackern-Oberti JP
PROVIDER: S-EPMC4200801 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Mackern-Oberti Juan P JP Vega Fabián F Llanos Carolina C Bueno Susan M SM Kalergis Alexis M AM
International journal of molecular sciences 20140916 9
Systemic autoimmune diseases can damage nearly every tissue or cell type of the body. Although a great deal of progress has been made in understanding the pathogenesis of autoimmune diseases, current therapies have not been improved, remain unspecific and are associated with significant side effects. Because dendritic cells (DCs) play a major role in promoting immune tolerance against self-antigens (self-Ags), current efforts are focusing at generating new therapies based on the transfer of tole ...[more]