Ontology highlight
ABSTRACT:
SUBMITTER: Adams DJ
PROVIDER: S-EPMC4201331 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Adams Drew J DJ Ito Daisuke D Rees Matthew G MG Seashore-Ludlow Brinton B Puyang Xiaoling X Ramos Alex H AH Cheah Jaime H JH Clemons Paul A PA Warmuth Markus M Zhu Ping P Shamji Alykhan F AF Schreiber Stuart L SL
ACS chemical biology 20140807 10
The small-molecule probes STF-31 and its analogue compound 146 were discovered while searching for compounds that kill VHL-deficient renal cell carcinoma cell lines selectively and have been reported to act via direct inhibition of the glucose transporter GLUT1. We profiled the sensitivity of 679 cancer cell lines to STF-31 and found that the pattern of response is tightly correlated with sensitivity to three different inhibitors of nicotinamide phosphoribosyltransferase (NAMPT). We also perform ...[more]