Ontology highlight
ABSTRACT:
SUBMITTER: Dana S
PROVIDER: S-EPMC4201339 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
ACS chemical biology 20140814 10
Malaria continues to be a major health problem globally. There is an urgent need to find new antimalarials. Acriflavine (ACF) is known as an antibacterial agent and more recently as an anticancer agent. Here, we report that ACF inhibits the growth of asexual stages of both chloroquine (CQ) sensitive and resistant strains of human malarial parasite, Plasmodium falciparum in vitro at nanomolar concentration. ACF clears the malaria infection in vivo from the bloodstreams of mice infected with Plasm ...[more]