Ontology highlight
ABSTRACT:
SUBMITTER: Aguiar ACC
PROVIDER: S-EPMC6215995 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
International journal for parasitology. Drugs and drug resistance 20181013 3
In spite of recent efforts to eradicate malaria in the world, this parasitic disease is still considered a major public health problem, with a total of 216 million cases of malaria and 445,000 deaths in 2016. Artemisinin-based combination therapies remain effective in most parts of the world, but recent cases of resistance in Southeast Asia have urged for novel approaches to treat malaria caused by Plasmodium falciparum. In this work, we present chloroquine analogs that exhibited high activity a ...[more]