Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis.
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ABSTRACT:
SUBMITTER: Schittek B
PROVIDER: S-EPMC4201705 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis.
Schittek Birgit B Sinnberg Tobias T
Molecular cancer 20141011
Isoforms of the casein kinase 1 (CK1) family have been shown to phosphorylate key regulatory molecules involved in cell cycle, transcription and translation, the structure of the cytoskeleton, cell-cell adhesion and receptor-coupled signal transduction. They regulate key signaling pathways known to be critically involved in tumor progression. Recent results point to an altered expression or activity of different CK1 isoforms in tumor cells. This review summarizes the expression and biological fu ...[more]
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