Unknown

Dataset Information

0

Casein kinase 1?: biological mechanisms and theranostic potential.

ABSTRACT: Casein kinase 1? (CK1?) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, cell cycle progression, chromosome segregation, apoptosis, autophagy, cell metabolism, and differentiation in development, circadian rhythm, and the immune response as well as neurodegeneration and cancer. Given its involvement in diverse cellular, physiological, and pathological processes, CK1? is a promising therapeutic target. In this review, we summarize what is known of the biological functions of CK1?, and provide an overview of existing challenges and potential opportunities for advancing theranostics.

SUBMITTER: Jiang S 

PROVIDER: S-EPMC5968562 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Casein kinase 1α: biological mechanisms and theranostic potential.

Jiang Shaojie S   Zhang Miaofeng M   Sun Jihong J   Yang Xiaoming X  

Cell communication and signaling : CCS 20180524 1

Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, cell cycle progression, chromosome segregation, apoptosis, autophagy, cell metabolism, and differentiation in development, circadian rhythm, and the immune response as well as neurodegeneration and cancer. Given its involvement in diverse cellular, physiological, and pathological processes,  ...[more]

Similar Datasets

Unknown Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis.
| S-EPMC4201705 | biostudies-literature
Unknown Biological functions and theranostic potential of HMGB family members in human cancers.
| S-EPMC7659026 | biostudies-literature
Unknown Phosphorylation by casein kinase II alters the biological activity of calmodulin.
| S-EPMC1130984 | biostudies-other
Unknown Interactions between Casein kinase Iepsilon (CKIepsilon) and two substrates from disparate signaling pathways reveal mechanisms for substrate-kinase specificity.
| S-EPMC2651596 | biostudies-literature
Unknown Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1? and frizzled5.
| S-EPMC4156093 | biostudies-literature
Unknown Mechanisms and consequences of casein kinase II and ankyrin-3 regulation of the epithelial Na<sup>+</sup> channel.
| S-EPMC8285517 | biostudies-literature
Unknown Crystal structure of the Golgi casein kinase.
| S-EPMC3696822 | biostudies-literature
Unknown Casein kinase 2 is essential for mitophagy.
| S-EPMC3790056 | biostudies-literature
Unknown Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
| S-EPMC2955617 | biostudies-literature
Unknown Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide.
| S-EPMC6800621 | biostudies-literature