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Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics.

ABSTRACT: The nuclear transcription factor c-Myc is a member of the Myc gene family with multiple functions and located on band q24.1 of chromosome 8. The c-Myc gene is activated by chromosomal translocation, rearrangement, and amplification. Its encoded protein transduces intracellular signals to the nucleus, resulting in the regulation of cell proliferation, differentiation, and apoptosis, and has the ability to transform cells and bind chromosomal DNA. c-Myc also plays a critical role in malignant transformation. The abnormal over-expression of c-Myc is frequently observed in some tumors, including carcinomas of the breast, colon, and cervix, as well as small-cell lung cancer, osteosarcomas, glioblastomas, and myeloid leukemias, therefore making it a possible target for anticancer therapy. In this minireview, we summarize unique characteristics of c-Myc and therapeutic strategies against cancer using small molecules targeting the oncogene, and discuss the prospects in the development of agents targeting c-Myc, in particular G-quadruplexes formed in c-Myc promoter and c-Myc/Max dimerization. Such information will be of importance for the research and development of c-Myc-targeted drugs.

SUBMITTER: Chen BJ

PROVIDER: S-EPMC4202025 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics.

Chen Bing-Jia BJ Wu Yan-Ling YL Tanaka Yoshimasa Y Zhang Wen W

International journal of biological sciences 20140913 10

The nuclear transcription factor c-Myc is a member of the Myc gene family with multiple functions and located on band q24.1 of chromosome 8. The c-Myc gene is activated by chromosomal translocation, rearrangement, and amplification. Its encoded protein transduces intracellular signals to the nucleus, resulting in the regulation of cell proliferation, differentiation, and apoptosis, and has the ability to transform cells and bind chromosomal DNA. c-Myc also plays a critical role in malignant tran ...[more]

PMID: 25332683

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Dataset Information

Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics.

Publications

Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics.

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