Ontology highlight
ABSTRACT:
SUBMITTER: Zhang T
PROVIDER: S-EPMC6137146 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Zhang Tao T Li Jingjie J He Yuan Y Yang Feifei F Hao Yun Y Jin Wangrui W Wu Jing J Sun Zhenliang Z Li Yunqi Y Chen Yihua Y Chen Yihua Y Yi Zhengfang Z Liu Mingyao M
Nature communications 20180913 1
Breast cancer is one of the most lethal cancers in women when it reaches the metastatic stage. Here, we screen a library of small molecules for inhibitors of breast cancer cell invasion, and use structure/activity relationship studies to develop a series of small molecules with improved activity. We find WJ460 as one of the lead compounds exerting anti-metastatic activity in the nanomolar range in breast cancer cells. Proteomic and biochemical studies identify myoferlin (MYOF) as the direct targ ...[more]