Ontology highlight
ABSTRACT:
SUBMITTER: Wilson C
PROVIDER: S-EPMC4202126 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Wilson Catherine C Nicholes Katrina K Bustos Daisy D Lin Eva E Song Qinghua Q Stephan Jean-Philippe JP Kirkpatrick Donald S DS Settleman Jeff J
Oncotarget 20140901 17
Epithelial to mesenchymal transition (EMT) is a key process in embryonic development and has been associated with cancer metastasis and drug resistance. For example, in EGFR mutated non-small cell lung cancers (NSCLC), EMT has been associated with acquired resistance to the EGFR inhibitor erlotinib. Moreover, "EGFR-addicted" cancer cell lines induced to undergo EMT become erlotinib-resistant in vitro. To identify potential therapeutic vulnerabilities specifically within these mesenchymal, erloti ...[more]