Ontology highlight
ABSTRACT:
SUBMITTER: Lee JJ
PROVIDER: S-EPMC6142214 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Lee Jaewon J JJ van de Ven Robert A H RAH Zaganjor Elma E Ng Mei Rosa MR Barakat Amey A Demmers Joris J P G JJPG Finley Lydia W S LWS Gonzalez Herrera Karina N KN Hung Yin Pun YP Harris Isaac S IS Jeong Seung Min SM Danuser Gaudenz G McAllister Sandra S SS Haigis Marcia C MC
Proceedings of the National Academy of Sciences of the United States of America 20180618 27
Metastasis remains the leading cause of cancer mortality, and reactive oxygen species (ROS) signaling promotes the metastatic cascade. However, the molecular pathways that control ROS signaling relevant to metastasis are little studied. Here, we identify SIRT3, a mitochondrial deacetylase, as a regulator of cell migration via its control of ROS signaling. We find that, although mitochondria are present at the leading edge of migrating cells, SIRT3 expression is down-regulated during migration, r ...[more]