Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC4202149 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Zhang Zheng Z Faouzi Malika M Huang Junhao J Geerts Dirk D Yu Haijie H Fleig Andrea A Penner Reinhold R
Oncotarget 20140901 17
Intracellular levels of the divalent cations Ca2+ and Mg2+ are important regulators of cell cycle and proliferation. However, the precise mechanisms by which they are regulated in cancer remain incompletely understood. The channel kinases TRPM6 and TRPM7 are gatekeepers of human Ca2+/Mg2+ metabolism. Here, we investigated the human neuroblastoma cell line SHEP-21N in which the MYCN oncogene (encoding N-Myc) can be reversibly expressed under control of an inducible repressor. We report that N-Myc ...[more]