Ontology highlight
ABSTRACT:
SUBMITTER: Hadjidaniel MD
PROVIDER: S-EPMC5710942 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Hadjidaniel Michael D MD Muthugounder Sakunthala S Hung Long T LT Sheard Michael A MA Shirinbak Soheila S Chan Randall Y RY Nakata Rie R Borriello Lucia L Malvar Jemily J Kennedy Rebekah J RJ Iwakura Hiroshi H Akamizu Takashi T Sposto Richard R Shimada Hiroyuki H DeClerck Yves A YA Asgharzadeh Shahab S
Oncotarget 20170916 53
Tumor-associated macrophages (TAMs) are strongly associated with poor survival in neuroblastomas that lack <i>MYCN</i> amplification. To study TAM action in neuroblastomas, we used a novel murine model of spontaneous neuroblastoma lacking <i>MYCN</i> amplification, and observed recruitment and polarization of TAMs, which in turn enhanced neuroblastoma proliferation and growth. In both murine and human neuroblastoma cells, we found that TAMs increased STAT3 activation in neuroblastoma cells and t ...[more]