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Ammonium ylides for the diastereoselective synthesis of glycidic amides.

ABSTRACT: A highly trans-selective protocol for the synthesis of glycidic amides was developed. This approach gave access to oxiranes by reacting stabilised ammonium ylides bearing an ?-carbonyl group and aromatic aldehydes in moderate to good yields.

SUBMITTER: Waser M

PROVIDER: S-EPMC4202193 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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Ammonium ylides for the diastereoselective synthesis of glycidic amides.

Waser Mario M Herchl Richard R Müller Norbert N

Chemical communications (Cambridge, England) 20101221 7

A highly trans-selective protocol for the synthesis of glycidic amides was developed. This approach gave access to oxiranes by reacting stabilised ammonium ylides bearing an α-carbonyl group and aromatic aldehydes in moderate to good yields. ...[more]

PMID: 21180720

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