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Synthesis of Trifluoroacetyl-Substituted Cyclopropanes Using Onium Ylides.

ABSTRACT: The use of carbonyl-stabilized ammonium- and sulfonium ylides allows for the synthesis of highly-functionalized trifluoroacetyl-substituted cyclopropanes. It turned out that the diastereoselectivities strongly depend on the nature of the chosen ylide and the employed base. The products could be obtained in good yields under operationally simple conditions.

SUBMITTER: Winter M

PROVIDER: S-EPMC5817241 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Synthesis of Trifluoroacetyl-Substituted Cyclopropanes Using Onium Ylides.

Winter Michael M Gaunersdorfer Christina C Roiser Lukas L Zielke Katharina K Monkowius Uwe U Waser Mario M

European journal of organic chemistry 20180122 3

The use of carbonyl-stabilized ammonium- and sulfonium ylides allows for the synthesis of highly-functionalized trifluoroacetyl-substituted cyclopropanes. It turned out that the diastereoselectivities strongly depend on the nature of the chosen ylide and the employed base. The products could be obtained in good yields under operationally simple conditions. ...[more]

PMID: 29491744

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