Deep cortical layers are activated directly by thalamus.
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ABSTRACT:
SUBMITTER: Constantinople CM
PROVIDER: S-EPMC4203320 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Deep cortical layers are activated directly by thalamus.
Constantinople Christine M CM Bruno Randy M RM
Science (New York, N.Y.) 20130601 6140
The thalamocortical (TC) projection to layer 4 (L4) is thought to be the main route by which sensory organs communicate with cortex. Sensory information is believed to then propagate through the cortical column along the L4→L2/3→L5/6 pathway. Here, we show that sensory-evoked responses of L5/6 neurons in rats derive instead from direct TC synapses. Many L5/6 neurons exhibited sensory-evoked postsynaptic potentials with the same latencies as L4. Paired in vivo recordings from L5/6 neurons and tha ...[more]
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