SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
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ABSTRACT:
SUBMITTER: Ming M
PROVIDER: S-EPMC4203414 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.
Ming Mei M Han Weinong W Zhao Baozhong B Sundaresan Nagalingam R NR Deng Chu-Xia CX Gupta Mahesh P MP He Yu-Ying YY
Cancer research 20141001 20
SIRT6 is a SIR2 family member that regulates multiple molecular pathways involved in metabolism, genomic stability, and aging. It has been proposed previously that SIRT6 is a tumor suppressor in cancer. Here, we challenge this concept by presenting evidence that skin-specific deletion of SIRT6 in the mouse inhibits skin tumorigenesis. SIRT6 promoted expression of COX-2 by repressing AMPK signaling, thereby increasing cell proliferation and survival in the skin epidermis. SIRT6 expression in skin ...[more]
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