ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response.
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ABSTRACT:
SUBMITTER: Lee SH
PROVIDER: S-EPMC4203664 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response.
Lee Sue Hyun SH Boire Timothy C TC Lee Jung Bok JB Gupta Mukesh K MK Zachman Angela L AL Rath Rutwik R Sung Hak-Joon HJ
Journal of materials chemistry. B 20141101 41
A reactive oxygen species (ROS)-degradable scaffold is fabricated by crosslinking biocompatible, hydrolytically-degradable poly(ε-caprolactone) (PCL) with a ROS-degradable oligoproline peptide, KP<sub>7</sub>K. The ROS-mediated degradability triggers favorable host responses of the scaffold including improved cell infiltration and angiogenesis <i>in vivo</i>, indicating its unique advantages for tissue engineering applications. ...[more]
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