Ontology highlight
ABSTRACT:
SUBMITTER: Schirmeyer J
PROVIDER: S-EPMC4203749 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Channels (Austin, Tex.) 20140101 3
The voltage-gated sodium channel Na(V)1.8 (encoded by SCN10A) is predominantly expressed in dorsal root ganglia(DRG) and plays a critical role in pain perception. We analyzed SCN10A transcripts isolated from human DRGs using deep sequencing and found a novel splice variant lacking exon 11, which codes for 98 amino acids of the domain I/II linker. Quantitative PCR analysis revealed an abundance of this variant of up to 5–10% in human, while no such variants were detected in mouse or rat. Since no ...[more]