Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5433841 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Zhang Xiulin X Priest Birgit T BT Belfer Inna I Gold Michael S MS
eLife 20170516
Available evidence indicates voltage-gated Na<sup>+</sup> channels (VGSCs) in peripheral sensory neurons are essential for the pain and hypersensitivity associated with tissue injury. However, our understanding of the biophysical and pharmacological properties of the channels in sensory neurons is largely based on the study of heterologous systems or rodent tissue, despite evidence that both expression systems and species differences influence these properties. Therefore, we sought to determine ...[more]