Ontology highlight
ABSTRACT:
SUBMITTER: Chan LS
PROVIDER: S-EPMC4203807 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
PloS one 20141020 10
Brain-specific AP180 is present in clathrin coats at equal concentration to the adapter complex, AP2, and assembles clathrin faster than any other protein in vitro. Both AP180 and its ubiquitously expressed homolog clathrin assembly lymphoid myeloid leukemia protein (CALM) control vesicle size and shape in clathrin mediated endocytosis. The clathrin assembly role of AP180 is mediated by a long disordered C-terminal assembly domain. Within this assembly domain, a central acidic clathrin and adapt ...[more]