Ontology highlight
ABSTRACT:
SUBMITTER: Morris SA
PROVIDER: S-EPMC413251 | biostudies-other | 1993 Feb
REPOSITORIES: biostudies-other
The EMBO journal 19930201 2
Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats. The largest rat brain cDNA clone isolated predicts a molecular weight of 91,430 for AP180. Two cDNA clones have an additional small 57 bp insert. The deduced molecular weight agrees with gel filtration results provided the more chaotropic denaturant 6 M guanidinium thiocyanate is substituted for the weaker guanidinium chloride. The sequence and the proteolytic cleavage pattern suggest a three domain structure. The ...[more]