Ontology highlight
ABSTRACT:
SUBMITTER: Arai S
PROVIDER: S-EPMC4204065 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Arai Satoshi S Lee Sung-Chan SC Zhai Duanting D Suzuki Madoka M Chang Young Tae YT
Scientific reports 20141021
The dynamics of cellular heat production and propagation remains elusive at a subcellular level. Here we report the first small molecule fluorescent thermometer selectively targeting the endoplasmic reticulum (ER thermo yellow), with the highest sensitivity reported so far (3.9%/°C). Unlike nanoparticle thermometers, ER thermo yellow stains the target organelle evenly without the commonly encountered problem of aggregation, and successfully demonstrates the ability to monitor intracellular tempe ...[more]