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Dry age-related macular degeneration: A currently unmet clinical need.


ABSTRACT: Age-related macular degeneration (AMD) is a leading cause of severe visual impairment and disability in older people worldwide. Although considerable advances in the management of the neovascular form of AMD have been made in the last decade, no therapy is yet available for the advanced dry form of AMD (geographic atrophy). This review focuses on current trends in the development of new therapies targeting specific pathophysiological pathways of dry AMD. Increased understanding of the complex mechanisms that underlie dry AMD will help to address this largely unmet clinical need.

SUBMITTER: Girmens JF 

PROVIDER: S-EPMC4204600 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Dry age-related macular degeneration: A currently unmet clinical need.

Girmens Jean-François JF   Sahel José-Alain JA   Marazova Katia K  

Intractable & rare diseases research 20120801 3


Age-related macular degeneration (AMD) is a leading cause of severe visual impairment and disability in older people worldwide. Although considerable advances in the management of the neovascular form of AMD have been made in the last decade, no therapy is yet available for the advanced dry form of AMD (geographic atrophy). This review focuses on current trends in the development of new therapies targeting specific pathophysiological pathways of dry AMD. Increased understanding of the complex me  ...[more]

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