Ontology highlight
ABSTRACT:
SUBMITTER: Blum B
PROVIDER: S-EPMC4204634 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Blum Barak B Roose Adam N AN Barrandon Ornella O Maehr René R Arvanites Anthony C AC Davidow Lance S LS Davis Jeffrey C JC Peterson Quinn P QP Rubin Lee L LL Melton Douglas A DA
eLife 20140916
Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes (T2D) lower blood glucose levels but they do not directly alleviate β cell stress nor prevent, let alone reverse, β cell de-differentiation. We show here that Urocortin 3 (Ucn3), a marker for mature β cells, is down-regulated in the early stages of T2D in mice and when β cells are stressed in vitro. Using an insul ...[more]