Dataset Information

A method to noninvasively identify cardiac bioelectrical sources.

ABSTRACT: We have introduced a method to guide radiofrequency catheter ablation (RCA) procedures that estimates the location of a catheter tip used to pace the ventricles and the target site for ablation using the single equivalent moving dipole (SEMD).To investigate the accuracy of this method in resolving epicardial and endocardial electrical sources.Two electrode arrays, each of nine pacing electrodes at known distances from each other, sutured on the left- and right-ventricular (LV and RV) epicardial surfaces of swine, were used to pace the heart at multiple rates, while body surface potentials from 64 sites were recorded and used to estimate the SEMD location. A similar approach was followed for pacing from catheters in the LV and RV.The overall (RV & LV) error in estimating the interelectrode distance of adjacent epicardial electrodes was 0.38 ± 0.45 cm. The overall endocardial (RV & LV) interelectrode distance error, was 0.44 ± 0.26 cm. Heart rate did not significantly affect the error of the estimated SEMD location (P > 0.05). The guiding process error became progressively smaller as the SEMD approached an epicardial target site and close to the target, the overall absolute error was ? 0.28 cm. The estimated epicardial SEMD locations preserved their topology in image space with respect to their corresponding physical location of the epicardial electrodes.The proposed algorithm suggests one can efficiently and accurately resolve epicardial electrical sources without the need of an imaging modality. In addition, the error in resolving these sources is sufficient to guide RCA procedures.

SUBMITTER: Sohn K

PROVIDER: S-EPMC4205085 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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A method to noninvasively identify cardiac bioelectrical sources.

Sohn Kwanghyun K Lv Wener W Lee Kichang K Galea Anna A Hirschman Gordon G Barrett Conor C Cohen Richard J RJ Armoundas Antonis A AA

Pacing and clinical electrophysiology : PACE 20140320 8

<h4>Background</h4>We have introduced a method to guide radiofrequency catheter ablation (RCA) procedures that estimates the location of a catheter tip used to pace the ventricles and the target site for ablation using the single equivalent moving dipole (SEMD).<h4>Objective</h4>To investigate the accuracy of this method in resolving epicardial and endocardial electrical sources.<h4>Methods</h4>Two electrode arrays, each of nine pacing electrodes at known distances from each other, sutured on th ...[more]

PMID: 24645803

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Project description:BACKGROUNDSudden cardiac death (SCD) remains a worldwide public health problem in need of better noninvasive predictive tools. Current guidelines for primary preventive SCD therapies, such as implantable cardioverter defibrillators (ICDs), are based on left ventricular ejection fraction (LVEF), but these guidelines are imprecise: fewer than 5% of ICDs deliver lifesaving therapy per year. Impaired cardiac metabolism and ATP depletion cause arrhythmias in experimental models, but to our knowledge a link between arrhythmias and cardiac energetic abnormalities in people has not been explored, nor has the potential for metabolically predicting clinical SCD risk.METHODSWe prospectively measured myocardial energy metabolism noninvasively with phosphorus magnetic resonance spectroscopy in patients with no history of significant arrhythmias prior to scheduled ICD implantation for primary prevention in the setting of reduced LVEF (≤35%).RESULTSBy 2 different analyses, low myocardial ATP significantly predicted the composite of subsequent appropriate ICD firings for life-threatening arrhythmias and cardiac death over approximately 10 years. Life-threatening arrhythmia risk was approximately 3-fold higher in patients with low ATP and independent of established risk factors, including LVEF. In patients with normal ATP, rates of appropriate ICD firings were several-fold lower than reported rates of ICD complications and inappropriate firings.CONCLUSIONTo the best of our knowledge, these are the first data linking in vivo myocardial ATP depletion and subsequent significant arrhythmic events in people, suggesting an energetic component to clinical life-threatening ventricular arrhythmogenesis. The findings support investigation of metabolic strategies that limit ATP loss to treat or prevent life-threatening cardiac arrhythmias and herald noninvasive metabolic imaging as a complementary SCD risk stratification tool.TRIAL REGISTRATIONClinicalTrials.gov NCT00181233.FUNDINGThis work was supported by the DW Reynolds Foundation, the NIH (grants HL61912, HL056882, HL103812, HL132181, HL140034), and Russell H. Morgan and Clarence Doodeman endowments at Johns Hopkins.

Project description:The dataset provided in this article are related to the research article entitled "The Journey of Universal Hybrid-pi model-from its Inception to Experimental Validation and its impact on Analog Circuit Design" (Sharma, in press). While analyzing dataset of the incremental output impedances of the BJT Current Sources, Conventional Hybrid-pi model, and Unilateral Model grossly underestimate the output impedances whereas Universal Hybrid-pi Model gives a much larger range of output impedances from ro to 40ro. The quest for these enhanced prediction led to the discovery of "Variable Latching Effect" (Sharma, 1990). Furthermore the ascending order of the dataset of Break-over voltages of Device-under-Test (DUT) were obeyed by the dataset predictions of incremental output impedance by Universal Model but not obeyed by those made by Conventional Model and Unilateral model. Direct experimental measurement of output impedances of current sources using laboratory setup validated Universal Hybrid-pi Model (Sharma, 2003) [3] but the results were inconclusive. The experimental measurement of the incremental output impedances by a Professional setup was also done and verified by analytical results. All incremental analysis is carried out at a given Q-point and Q-point decides the incremental parameters of the Hybrid-pi model and T-model which are to be used in the analytic relations (2), (3) and (4) given in the main text (Sharma, in press). Q-points of the current sources at which the output impedance measurement have been made are given in this dataset (see Table 6). Model parameters at the given Q-points are derived from simple analytic relations given in the main text (Sharma, in press) and tabulated in Table 7 and Table 7A. The theoretical incremental output impedance are calculated for the conventional model, universal model and T-model and compared with the experimentally measured values of output impedance and tabulated in this dataset (see Table 8 and Figure 8). A very high gain Differential Amplifier?s incremental voltage gain is experimentally measured and analytically verified. The experimental values and Universal Hybrid-pi model theoretical analytic results are given . The conventional model analytic results for incremental voltage gains are also tabulated. This article data is being made publicly available to enable critical or extended analysis.

Dataset Information

A method to noninvasively identify cardiac bioelectrical sources.

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A method to noninvasively identify cardiac bioelectrical sources.

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