Ontology highlight
ABSTRACT:
SUBMITTER: Lin CC
PROVIDER: S-EPMC4205158 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Lin Chun-Chi CC Huoh Yu-San YS Schmitz Karl R KR Jensen Liselotte E LE Ferguson Kathryn M KM
Structure (London, England : 1993) 20081201 12
Pellino proteins are RING E3 ubiquitin ligases involved in signaling events downstream of the Toll and interleukin-1 (IL-1) receptors, key initiators of innate immune and inflammatory responses. Pellino proteins associate with and ubiquitinate proteins in these pathways, including the interleukin-1 receptor associated kinase-1 (IRAK1). We determined the X-ray crystal structure of a Pellino2 fragment lacking only the RING domain. This structure reveals that the IRAK1-binding region of Pellino pro ...[more]