Ontology highlight
ABSTRACT:
SUBMITTER: Warren JT
PROVIDER: S-EPMC4206197 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Warren Julia T JT Nelson Christopher A CA Decker Corinne E CE Zou Wei W Fremont Daved H DH Teitelbaum Steven L SL
Science signaling 20140819 339
Signaling by receptor activator of nuclear factor κB (RANK) in response to its ligand RANKL, which is a member of the tumor necrosis factor (TNF) superfamily of cytokines, stimulates osteoclast formation and bone resorption. Thus, this ligand-receptor pair is a therapeutic target for various disorders, such as osteoporosis and metastasis of cancer to bone. RANKL exists as a physiological homotrimer, with each monomer recognizing a single molecule of RANK or the decoy receptor osteoprotegerin (OP ...[more]