Ontology highlight
ABSTRACT:
SUBMITTER: Iwahashi K
PROVIDER: S-EPMC4206383 | biostudies-literature | 2014 Jul-Aug
REPOSITORIES: biostudies-literature
Clinical neuropharmacology 20140701 4
The GSK-3β gene, GSK3B, codes for an enzyme that is a target for the action of mood stabilizers, lithium and possibly valproic acid.In this study, the relationship between haplotypes consisting of single nucleotide polymorphisms (SNPs) of GSK3B -50T/C and -1727A/T and the effect of lithium was studied among Japanese bipolar disorder lithium nonresponders and responders.The distributions of the GSK3B haplotypes (-50T/C and -1727A/T) showed a trend for significant difference between the lithium no ...[more]