Ontology highlight
ABSTRACT:
SUBMITTER: Woo CM
PROVIDER: S-EPMC4206835 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Woo Christina M CM Ranjan Nihar N Arya Dev P DP Herzon Seth B SB
Angewandte Chemie (International ed. in English) 20140709 35
The lomaiviticins and kinamycins are complex DNA damaging natural products that contain a diazofluorene functional group. Herein, we elucidate the influence of skeleton structure, ring and chain isomerization, D-ring oxidation state, and naphthoquinone substitution on DNA binding and damaging activity. We show that the electrophilicity of the diazofluorene appears to be a significant determinant of DNA damaging activity. These studies identify the monomeric diazofluorene 11 as a potent DNA cleav ...[more]