Targeting the androgen receptor with steroid conjugates.
Ontology highlight
ABSTRACT:
SUBMITTER: Levine PM
PROVIDER: S-EPMC4207530 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Targeting the androgen receptor with steroid conjugates.
Levine Paul M PM Garabedian Michael J MJ Kirshenbaum Kent K
Journal of medicinal chemistry 20140708 20
The androgen receptor (AR) is a major therapeutic target in prostate cancer pharmacology. Progression of prostate cancer has been linked to elevated expression of AR in malignant tissue, suggesting that AR plays a central role in prostate cancer cell biology. Potent therapeutic agents can be precisely crafted to specifically target AR, potentially averting systemic toxicities associated with nonspecific chemotherapies. In this review, we describe various strategies to generate steroid conjugates ...[more]
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