Ontology highlight
ABSTRACT:
SUBMITTER: Oganesyan V
PROVIDER: S-EPMC4207998 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Oganesyan Vaheh V Peng Li L Damschroder Melissa M MM Cheng Li L Sadowska Agnieszka A Tkaczyk Christine C Sellman Bret R BR Wu Herren H Dall'Acqua William F WF
The Journal of biological chemistry 20140910 43
MEDI4893 is a neutralizing human monoclonal antibody that targets α-toxin (AT) and is currently undergoing evaluation in the field of Staphylococcus aureus-mediated diseases. We have solved the crystal structure of MEDI4893 Fab bound to monomeric AT at a resolution of 2.56 Å and further characterized its epitope using various engineered AT variants. We have found that MEDI4893 recognizes a novel epitope in the so-called "rim" domain of AT and exerts its neutralizing effect through a dual mechani ...[more]