Ontology highlight
ABSTRACT:
SUBMITTER: Greenall SA
PROVIDER: S-EPMC4966628 | biostudies-literature | 2016 Feb-Mar
REPOSITORIES: biostudies-literature
Greenall Sameer A SA Adams Timothy E TE Johns Terrance G TG
mAbs 20160201 2
The antibody rilotumumab, which has been tested in multiple Phase 2 and Phase 3 trials, has been reported to neutralize hepatocyte growth factor (HGF), the ligand for the oncogene MET. However, we report that rilotumumab does not prevent HGF from directly binding to MET on conventional and primary patient-derived human gliomasphere lines, a trait driven by the HGF α-chain, which remains free to engage cell-surface glycosaminoglycans and the receptor MET. This binding induces MET phosphorylation, ...[more]