Ontology highlight
ABSTRACT:
SUBMITTER: Conn PJ
PROVIDER: S-EPMC4208620 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Nature reviews. Drug discovery 20140901 9
Novel allosteric modulators of G protein-coupled receptors (GPCRs) are providing fundamental advances in the development of GPCR ligands with high subtype selectivity and novel modes of efficacy that have not been possible with traditional approaches. As new allosteric modulators are advancing as drug candidates, we are developing an increased understanding of the major advantages and broad range of activities that can be achieved with these agents through selective modulation of specific signal ...[more]