Ontology highlight
ABSTRACT:
SUBMITTER: Rosean TR
PROVIDER: S-EPMC4209159 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Rosean Timothy R TR Tompkins Van S VS Tricot Guido G Holman Carol J CJ Olivier Alicia K AK Zhan Fenghuang F Janz Siegfried S
Immunologic research 20140801 1-3
Studies on the biologic and molecular genetic underpinnings of multiple myeloma (MM) have identified the pleiotropic, pro-inflammatory cytokine, interleukin-6 (IL-6), as a factor crucial to the growth, proliferation and survival of myeloma cells. IL-6 is also a potent stimulator of osteoclastogenesis and a sculptor of the tumor microenvironment in the bone marrow of patients with myeloma. This knowledge has engendered considerable interest in targeting IL-6 for therapeutic purposes, using a vari ...[more]