Ontology highlight
ABSTRACT:
SUBMITTER: Otsmane B
PROVIDER: S-EPMC4210091 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Otsmane Belkacem B Moumen Anice A Aebischer Julianne J Coque Emmanuelle E Sar Chamroeun C Sunyach Claire C Salsac Céline C Valmier Jean J Salinas Sara S Bowerman Melissa M Raoul Cédric C
EMBO reports 20140324 5
A receptor-ligand interaction can evoke a broad range of biological activities in different cell types depending on receptor identity and cell type-specific post-receptor signaling intermediates. Here, we show that the TNF family member LIGHT, known to act as a death-triggering factor in motoneurons through LT-βR, can also promote axon outgrowth and branching in motoneurons through the same receptor. LIGHT-induced axonal elongation and branching require ERK and caspase-9 pathways. This distinct ...[more]