Ontology highlight
ABSTRACT:
SUBMITTER: Pathak A
PROVIDER: S-EPMC6093198 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Pathak Amrita A Stanley Emily M EM Hickman F Edward FE Wallace Natalie N Brewer Bryson B Li Deyu D Gluska Shani S Perlson Eran E Fuhrmann Sabine S Akassoglou Katerina K Bronfman Francisca F Casaccia Patrizia P Burnette Dylan T DT Carter Bruce D BD
Developmental cell 20180801 3
During development, neurons undergo apoptosis if they do not receive adequate trophic support from tissues they innervate or when detrimental factors activate the p75 neurotrophin receptor (p75NTR) at their axon ends. Trophic factor deprivation (TFD) or activation of p75NTR in distal axons results in a retrograde degenerative signal. However, the nature of this signal and the regulation of its transport are poorly understood. Here, we identify p75NTR intracellular domain (ICD) and histone deacet ...[more]