Ontology highlight
ABSTRACT:
SUBMITTER: Hsieh CL
PROVIDER: S-EPMC4210355 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Hsieh Christine L CL Kim Charles C CC Ryba Bryan E BE Niemi Erene C EC Bando Jennifer K JK Locksley Richard M RM Liu Jialing J Nakamura Mary C MC Seaman William E WE
European journal of immunology 20130605 8
Traumatic brain injury (TBI) elicits innate inflammatory responses that can lead to secondary brain injury. To better understand the mechanisms involved in TBI-induced inflammation, we examined the nature of macrophages responding to TBI in mice. In this model, brain macrophages were increased >20-fold the day after injury and >77-fold 4 days after injury in the ipsilateral hemisphere compared with sham controls. TBI macrophage subsets were identified by using a reporter mouse strain (YARG) that ...[more]