Traumatic Brain Injury Induces Tau Aggregation and Spreading.
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ABSTRACT:
SUBMITTER: Edwards G
PROVIDER: S-EPMC6921297 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Traumatic Brain Injury Induces Tau Aggregation and Spreading.
Edwards George G Zhao Jing J Dash Pramod K PK Soto Claudio C Moreno-Gonzalez Ines I
Journal of neurotrauma 20190828 1
The misfolding and aggregation of tau protein into neurofibrillary tangles is the main underlying hallmark of tauopathies. Most tauopathies have a sporadic origin and can be associated with multiple risk factors. Traumatic brain injury (TBI) has been suggested as a risk factor for tauopathies by triggering disease onset and facilitating its progression. Several studies indicate that TBI seems to be a risk factor to development of Alzheimer disease and chronic traumatic encephalopathy, because th ...[more]
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