Ontology highlight
ABSTRACT:
SUBMITTER: van Wijk DF
PROVIDER: S-EPMC4210837 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
van Wijk Diederik F DF van Leuven Sander I SI Sandhu Manjinder S MS Tanck Michael W MW Hutten Barbara A BA Wareham Nicholas J NJ Kastelein John J P JJ Stroes Erik S G ES Khaw Kay-Tee KT Boekholdt S Matthijs SM
Arteriosclerosis, thrombosis, and vascular biology 20100429 7
<h4>Objective</h4>In humans, evidence about the association between levels of monocyte chemoattractant protein-1 (MCP-1), its coding gene chemokine (C-C motif) ligand 2 (CCL2), and risk of coronary artery disease (CAD) is contradictory.<h4>Methods and results</h4>We performed a nested case-control study in the prospective EPIC-Norfolk cohort investigating the relationship between CCL2 single-nucleotide polymorphisms (SNPs), MCP-1 concentrations, and the risk of future CAD. Cases (n=1138) were ap ...[more]