Ontology highlight
ABSTRACT:
SUBMITTER: Leil TA
PROVIDER: S-EPMC4211262 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Leil T A TA Frost C C Wang X X Pfister M M LaCreta F F
CPT: pharmacometrics & systems pharmacology 20140917
Population pharmacokinetic (PK) and exposure-response analyses of apixaban were performed using data from phase I-III studies to predict bleeding risks for patients receiving apixaban 2.5 mg b.i.d. after total knee or hip replacement (TKR, THR) surgery (N = 5,510). Renal function, age, gender, and body weight impacted apixaban exposure. Bleeding risk increased as a function of exposure. Predicted bleeding frequencies for TKR and THR populations at risk for high apixaban exposure (female, age > 7 ...[more]