Ontology highlight
ABSTRACT:
SUBMITTER: Modell JW
PROVIDER: S-EPMC4211646 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Modell Joshua W JW Kambara Tracy K TK Perchuk Barrett S BS Laub Michael T MT
PLoS biology 20141028 10
Cells must coordinate DNA replication with cell division, especially during episodes of DNA damage. The paradigm for cell division control following DNA damage in bacteria involves the SOS response where cleavage of the transcriptional repressor LexA induces a division inhibitor. However, in Caulobacter crescentus, cells lacking the primary SOS-regulated inhibitor, sidA, can often still delay division post-damage. Here we identify didA, a second cell division inhibitor that is induced by DNA dam ...[more]