Reversal of anchorage-independent multicellular spheroid into a monolayer mimics a metastatic model.
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ABSTRACT:
SUBMITTER: Kunjithapatham R
PROVIDER: S-EPMC4212233 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Reversal of anchorage-independent multicellular spheroid into a monolayer mimics a metastatic model.
Kunjithapatham Rani R Karthikeyan Swathi S Geschwind Jean-Francois JF Kieserman Esther E Lin MingDe M Fu De-Xue DX Ganapathy-Kanniappan Shanmugasundaram S
Scientific reports 20141029
Lack of an in vitro model of metastasis has been a major impediment in understanding the molecular regulation of metastatic processes, and identification of specific therapeutic targets. We have established an in vitro model which displayed the signatures of metastatic phenotype such as migration, invasiveness, chemoresistance and expression of cancer stem-cell markers. This in vitro model was developed by the induction of reversal of multicellular spheroids that were generated by anchorage-inde ...[more]
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