Hypertension drives parenchymal ?-amyloid accumulation in the brain parenchyma.
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ABSTRACT:
SUBMITTER: Bueche CZ
PROVIDER: S-EPMC4212487 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
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Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma.
Bueche Celine Z CZ Hawkes Cheryl C Garz Cornelia C Vielhaber Stefan S Attems Johannes J Knight Robert T RT Reymann Klaus K Heinze Hans-Jochen HJ Carare Roxana O RO Schreiber Stefanie S
Annals of clinical and translational neurology 20140109 2
There is substantial controversy regarding the causative role of amyloid β (Aβ) deposition in Alzheimer's disease (AD). The cerebrovasculature plays an important role in the elimination of Aβ from the brain and hypertension is a well-known risk factor for AD. In spontaneously hypertensive stroke-prone rats (SHRSP), an animal model of chronic arterial hypertension, cerebral small vessel disease (CSVD) leads to age-dependent parenchymal Aβ accumulation similar to that observed in AD. These data ap ...[more]
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