Ontology highlight
ABSTRACT:
SUBMITTER: Thomas NA
PROVIDER: S-EPMC4213142 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Thomas Natalie A NA Koudijs Marco M van Eeden Fredericus J M FJ Joyner Alexandra L AL Yelon Deborah D
Development (Cambridge, England) 20081008 22
Elucidation of the complete roster of signals required for myocardial specification is crucial to the future of cardiac regenerative medicine. Prior studies have implicated the Hedgehog (Hh) signaling pathway in the regulation of multiple aspects of heart development. However, our understanding of the contribution of Hh signaling to the initial specification of myocardial progenitor cells remains incomplete. Here, we show that Hh signaling promotes cardiomyocyte formation in zebrafish. Reduced H ...[more]