Ontology highlight
ABSTRACT:
SUBMITTER: Herr KJ
PROVIDER: S-EPMC4213774 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Herr Keira Joann KJ Tsang Ying-hung Nicole YH Ong Joanne Wei En JW Li Qiushi Q Yap Lai Lai LL Yu Weimiao W Yin Hao H Bogorad Roman L RL Dahlman James E JE Chan Yee Gek YG Bay Boon Huat BH Singaraja Roshni R Anderson Daniel G DG Koteliansky Victor V Viasnoff Virgile V Thiery Jean Paul JP
Scientific reports 20141030
The liver is unique in its capacity to regenerate after injury, during which hepatocytes actively divide and establish cell-cell contacts through cell adhesion complexes. Here, we demonstrate that the loss of α-catenin, a well-established adhesion component, dramatically disrupts liver regeneration. Using a partial hepatectomy model, we show that regenerated livers from α-catenin knockdown mice are grossly larger than control regenerated livers, with an increase in cell size and proliferation. T ...[more]