Ontology highlight
ABSTRACT:
SUBMITTER: Lee PS
PROVIDER: S-EPMC4213955 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Breast cancer : basic and clinical research 20141012
Common genetic variants mapping to two distinct regions of RAD51B, a paralog of RAD51, have been associated with breast cancer risk in genome-wide association studies (GWAS). RAD51B is a plausible candidate gene because of its established role in the homologous recombination (HR) process. How germline genetic variation in RAD51B confers susceptibility to breast cancer is not well understood. Here, we investigate the molecular function of RAD51B in breast cancer cell lines by knocking down RAD51B ...[more]