Epigenetic alterations in depression and antidepressant treatment.
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ABSTRACT:
SUBMITTER: Menke A
PROVIDER: S-EPMC4214180 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Epigenetic alterations in depression and antidepressant treatment.
Menke Andreas A Binder Elisabeth B EB
Dialogues in clinical neuroscience 20140901 3
Epigenetic modifications control chromatin structure and function, and thus mediate changes in gene expression, ultimately influencing protein levels. Recent research indicates that environmental events can induce epigenetic changes and, by this, contribute to long-term changes in neural circuits and endocrine systems associated with altered risk for stress-related psychiatric disorders such as major depression. In this review, we describe recent approaches investigating epigenetic modifications ...[more]
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