Ontology highlight
ABSTRACT:
SUBMITTER: Shukla S
PROVIDER: S-EPMC4214796 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
PLoS pathogens 20141030 10
Mycobacterium tuberculosis (Mtb) virulence is decreased by genetic deletion of the lipoprotein LprG, but the function of LprG remains unclear. We report that LprG expressed in Mtb binds to lipoglycans, such as lipoarabinomannan (LAM), that mediate Mtb immune evasion. Lipoglycan binding to LprG was dependent on both insertion of lipoglycan acyl chains into a hydrophobic pocket on LprG and a novel contribution of lipoglycan polysaccharide components outside of this pocket. An lprG null mutant (Mtb ...[more]